San Diego, which has posted a 41-33 record since the All-Star break, will send to the mound left-hander Andrew Werner, who will be looking to snap a personal two-game losing streak.
For the 25-year-old Werner, a rookie, it will be just his eighth Major League start. In his last outing, a 3-1 home loss to the playoff-bound Giants, he gave up three runs on eight hits in just 4 2/3 innings. This will be his first start against the Brewers.
Yovani Gallardo was scheduled to start for Milwaukee, which won for the 22nd time in its last 27 home games on Tuesday night. Gallardo, who snapped an eight-game winning streak in his last start, will not go for his 17th win, however; Josh Stinson will instead take the mound.
The Brewers decided Gallardo has pitched enough in 2012 after making 33 starts for the second consecutive season, especially considering his heavy workload through the 2011 postseason.
Stinson, who has been pitching in relief this month, will make his first Major League start.Of Gallardo, manager Ron Roenicke said, "He's been our horse, and he really was last year, too, with his innings pitched. When you add in his playoff innings, he threw a lot last year."
Padres: Headley picks up monthly honors again
Chase Headley was named the National League Player of the Month for September on Tuesday, the second consecutive month he has earned the award.
The third baseman hit .324 with nine home runs and 30 RBIs in September, a month after hitting .306 with 10 homers and 31 RBIs.
"There's been so many more opportunities," Headley said of getting chances to hit with runners on base. "The second half has been incredibly enjoyable, especially being around these guys."
"It's a great honor, again. How often do you get to say that?" Padres manager Bud Black said. "Chase just kept going. Teams kept pitching him tougher, and he kept getting his hits."
Brewers: Coaching staff to return in 2013
Milwaukee's entire coaching staff will return for the 2013 season, manager Ron Roenicke said on Tuesday.
Roenicke's staff is made up of bench coach Jerry Narron, hitting coach Johnny Narron, pitching coach Rick Kranitz, first-base coach Garth Iorg, third-base coach Ed Sedar and bullpen coach Lee Tunnell. Tunnell joined the Brewers in late July after Stan Kyles was dismissed.
"Everybody is coming back," Roenicke said. "This is really a good staff."
Wednesday's game at Miller Park will decide the NL's 2012 RBI king, as Headley and Milwaukee's Ryan Braun are first and second with 113 and 112 RBIs, respectively.
Already having set career highs in hits (171), home runs (31), RBIs (113), runs scored (94) and walks (84), Headley needs just one more double and one more stolen base to tie two more career highs.