 |
Player | Position | Former Team | New Team | Transaction date | Notes | |
| 1. | Gonzalez, Adrian | 1B | SD | BOS | 12/06/10 | Traded for three minor league players and a PTBN | |
| 2. | Hermida, Jeremy | RF | SD | CLE | 2/05/13 | Minor league contract | |
| 3. | Patterson, Eric | OF | SD | DET | 12/16/11 | Minor league contract | |
| 4. | Mujica, Edward | P | SD | MIA | 11/13/10 | Traded with Ryan Webb for Cameron Maybin | |
| 5. | Webb, Ryan | P | SD | MIA | 11/13/10 | Traded with Edward Mujica for Cameron Maybin | |
| 6. | Gwynn, Tony | OF | SD | LAD | 12/11/10 | One-year contract | |
| 7. | Harang, Aaron | SP | SD | LAD | 12/08/11 | Two-year contract | |
| 8. | Buck, Travis | OF | HOU | SD | 11/28/12 | Minor league contract | |
| 9. | Flores, Randy | RP | MIN | SD | 2/27/11 | Minor league contract | |
| 10. | Frandsen, Kevin | IF | LAA | SD | 1/06/11 | Minor league contract | |
| 11. | Garcia, Freddy | SP | NYY | SD | 1/28/13 | Minor league contract | |
| 12. | Kotsay, Mark | OF | MIL | SD | 11/16/11 | One-year contract | |
| 13. | Maybin, Cameron | CF | MIA | SD | 11/13/10 | Traded for Edward Mujica and Ryan Webb | |
| 14. | Owings, Micah | SP | ARI | SD | 2/02/12 | One-year contract | |
| 15. | Perdomo, Luis | RP | SD | SD | 12/03/10 | Minor league contract | |
| 16. | Ransom, Cody | SS | ARI | SD | 1/03/13 | Minor league contract | |
| 17. | Thayer, Dale | RP | NYM | SD | 12/06/11 | Minor league contract | |
| 18. | Zaun, Gregg | C | MIL | SD | 1/19/11 | Minor league contract | |
| 19. | Gerut, Jody | OF | SD | SEA | 1/20/11 | Minor league contract | |
| 20. | Stewart, Chris | C | SD | SF | 12/22/10 | Minor league contract | |
| 21. | Tejada, Miguel | SS | SD | SF | 12/02/10 | One-year contract | |
| 22. | Hawpe, Brad | 1B | SD | TEX | 1/20/12 | Minor league contract | |
| 23. | Bartlett, Jason | SS | SD | --- | --- | Released | |
| 24. | Eckstein, David | 2B | SD | --- | --- | --- | |
| 25. | Moseley, Dustin | SP | SD | --- | --- | Minor league free agent | |
| 26. | Suppan, Jeff | SP | SD | --- | --- | Minor league free agent | |
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